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. 2024 Nov 30;10(1):60. doi: 10.1038/s41514-024-00187-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a UMAP plot depicting cell types in the human retina⁵⁹ (GEO: GSE148077). Cells detected include Rods, Cones, Retina Ganglion cells (RGCs), Bipolar cells (BCs), Amacrine cells (ACs), Horizontal cells (HCs), Mueller glia (MG), Astrocytes (Asc), Microglia (Mic) and Endothelial cells & Pericytes (ECs and Pericytes). b SenMayo enrichment score (ES) distribution in the human retina by cell type. c UMAP plot of human retina depicting SenMayo-hi cells. Mic cells score the highest. d Percentage of SenMayo-hi cells in different cell types in the human retina. e SenMayo-hi cells also score high for GenAge and CellAge gene sets. f Violin plots show the upregulation of MIF and AXL in SenMayo-hi cells in the human retina.