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. 2024 Nov 30;10:142. doi: 10.1038/s41540-024-00462-1

Fig. 2. Comparison of spatial cell distribution between whole tissue and microarray cores.

Fig. 2

A Top left image shows HE stained image of the tissue section spanning the whole fiducial frame. The image in the top right displays a HE-stained image of the microarray derived from the entire tissue. Notably, the five cores in the microarray (labeled as I, II, III, IV, V) were precisely extracted from the identical region from which the whole tissue was initially sectioned. The bottom two images show malignant cell fraction in the two tissue designs. B Average cell fractions for different cell types for whole tissue and microarray. For microarray, average fractions from all the five cores are depicted together. C Box plot with average cell fraction from any two unique microarray cores combined. D Cell fraction from 5 different microarray cores plotted separately. The top two components of Fig. 2A were annotated and created using Leica ImageScope, while the bottom components of Fig. 2A, B, C, and D were created in R.