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. 2024 Nov 30;7:1598. doi: 10.1038/s42003-024-07228-9

Fig. 1. Overall features of chemerin binding to the CMKLR1-Gi complex.

Fig. 1

a Cryo-EM density of chemerin-CMKLR1-Gi complex. b Overall structure of chemerin-CMKLR1-Gi complex at 3.18 Å. c Molecular structure of the mature human chemerin. The C-terminal nonapeptide (C9) loop is highlight in yellow. d Schematic illustration of chemerin binding to CMKLR1. Chemerin is shown in magenta, and CMKLR1 is shown in purple. Chemerin binding region 1 (CBR1) and 2 (CBR2) are marked with dashed squares. e Structure of chemerin, with disulfide bonds shown as sticks. f Structure of CXCL8 (PDB ID: 6LFO), with disulfide bonds shown as sticks. g Structure of CCL2 (PDB ID: 7XA3), with disulfide bonds shown as sticks.