Table 2.
Incidence and risk of incident IE
| HR (95% CI) | SHR(95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| HTN level | UW | Participants, No. | Event, No. | Person-years, No. | IR per 1000 PY | Model 1a | Model 2b | Model 3c |
| Normal | 374,586 | 168 | 2,596,618.93 | 0.0647 | 1 (Reference) | 1 (Reference) | 1 (Reference) | |
| Pre-HTN | 750,006 | 303 | 5,191,772.99 | 0.05836 | 0.903 (0.748-1.091) | 0.909 (0.752-1.097) | 0.918 (0.759- 1.109) | |
| HTN | 1,478,420 | 1,232 | 10,069,290.54 | 0.12235 | 1.892 (1.610-2.223) | 1.343 (1.138-1.585) | 1.360 (1.152-1.607) | |
| HR (95% CI) | SHR(95% CI) | |||||||
| Normal | No | 361,343 | 161 | 2,513,483·48 | 0.06405 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Yes | 13,243 | 7 | 83,135·44 | 0.0842 | 1.334 (0.626-2.843) | 1.180 (0.554-2.517) | 1.028 (0.482-2.194) | |
| Pre-HTN | No | 737,610 | 295 | 5,115,472·1 | 0.05767 | 0.902 (0.744-1.093) | 0.906 (0.747-1.098) | 0.913 (0.753-1.107) |
| Yes | 12,396 | 8 | 76,300·89 | 0.10485 | 1.663 (0.818-3.383) | 1.387 (0.681-2.825) | 1.209 (0.593-2.465) | |
| HTN | No | 1,462,441 | 1210 | 9981453.39 | 0.12122 | 1.894 (1.607-2.232) | 1.344 (1.135-1.590) | 1.357 (1.145-1.609) |
| Yes | 15,979 | 22 | 87,837·15 | 0.52046 | 4.012 (2.570-6.264) | 2.221 (1.418-3.481) | 1.748 (1.108-2.755) |
a Model 1 was unadjusted
b Model 2 was adjusted for age, sex, lower income (lowest Q1), smoking, drinking, regular exercise, diabetes duration, chronic kidney disease, dyslipidemia, insulin use and oral hypoglycemic agents (≥3 types)
c Model 3 was adjusted for age, sex, lower income (lowest Q1), smoking, drinking, regular exercise, diabetes duration, chronic kidney disease, dyslipidemia, insulin use and oral hypoglycemic agents (≥3 types), considering death as a competing event
CI, confidence interval; HR, hazard ratio; HTN, hypertension; IR, incidence rate; IE, infective endocarditis; SHR, subdistribution hazard ratio; UW, underweight