Table 2.
Baseline inflammatory biomarkers and indices concerning the endoscopic activity
| Variable | Patients with inactive endoscopy median (range) | Patients with active endoscopy median (range) | P value* |
|---|---|---|---|
| N. | 36/181 (20%) | 145/181 (80%) | |
| Fecal calprotectin (mg/kg) | 31.3 (3.8–402) | 192 (0–3770) | 0.001 |
| C-reactive protein (mg/L) | 1.4 (0.05–15.56) | 1.69 (0–279) | 0.28 |
| Albumin (g/dL) |
4.30 (3.72–4.97) | 4.01 (2.45–4.88) | 0.01 |
| Lymphocytes (X103/µL) |
2 (0.73–4.56) | 2.05 (0.5–23.7) | 0.96 |
| Neutrophil (×103/uL) |
4 (0.66–10.05) | 4.63 (0.7–228) | 0.04 |
| Platelets (×103/uL) |
234.5 (134–506) | 272 (0.7–651) | 0.002 |
| Monocytes (×103/uL) |
0.51 (0.21–0.90) | 0.53 (0.08–5.3) | 0.28 |
| Eosinophils (×103/uL) |
0.15 (0–0.66) | 0.13 (0–1.05) | 0.89 |
| SIRI | 0.97 (0.20–4.47) | 1.15 (0.15–20.1) | 0.01 |
| NLR | 1.90 (0.31–7.48) | 2.34 (0.43–49.6) | 0.02 |
| PLR | 114.25 (46.9–348.9) | 134.59 (0.14–833.3) | 0.04 |
| LMR | 4.04 (1.66–11.7) | 3.86 (0.31–24.7) | 0.25 |
| ELR | 0.06 (0–0.23) | 0.06 (0–0.7) | 1.00 |
| ENLR | 0.28 (0–1.29) | 0.29 (0–6.4) | 0.38 |
| CAR | 0.45 (0.02–2.7) | 0.42 (0–102.2) | 0.54 |
| SII | 465.93(55.5–1971.6) | 655.13 (8.9–8266.6) | 0.004 |
| MLR | 0.25 (0.09–0.6) | 0.26 (0.04–3.25) | 0.25 |
| AISI | 216.66 (36.6–1237.2) | 326.65 (9.07–10811.9) | 0.007 |
AISI, aggregate index of systemic inflammation; AUC, area under the curve; CAR, C-reactive protein albumin ratio; CALPRO, calprotectin; CI, confidence interval; CRP, C-reactive protein; ELR, eosinophil-to-lymphocytes ratio; ENLR, eosinophil and neutrophil-to-lymphocytes ratio; LMR, lymphocytes-to-monocytes ratio; MLR, monocytes-to-lymphocytes ratio; NLR, neutrophil-to-lymphocytes ratio; PLR, platelets-to-lymphocytes ratio; SII, systemic immune inflammation index; SIRI: Systemic inflammation response index.
*
P < 0.05 was considered statistically significant.