Table 3.
Baseline inflammatory biomarkers and indices concerning histologic activity
| Variable | Patients with inactive histology Median (range) |
Patients with active histology Median (range) |
P valuea |
|---|---|---|---|
| N. | 38/157 (24%) | 119/157 (76%) | |
| Fecal calprotectin (mg/kg) | 50.00 (0–2167) | 133.25 (5.4–3770) | 0.04 |
| C-reactive protein (mg/L) | 1.00 (0.02–15.56) | 2.07 (0–279) | 0.01 |
| Albumin (g/dL) |
4.26 (3.1–4.9) | 4.06 (2.45–4.8) | 0.09 |
| Lymphocytes (×103/uL) |
2.00 (0.7–3.7) | 2.12 (0.5–23.7) | 0.43 |
| Neutrophil (×103/uL) |
3.82 (0.6–12.7) | 4.70 (1.38–228) | 0.007 |
| Platelets (×103/uL) |
246.50 (174–529) | 265.00 (0.7–651) | 0.33 |
| Monocytes (×103 uL) |
0.52 (0.28–1.07) | 0.56 (0.08–5.30) | 0.27 |
| Eosinophils (×103 uL) |
0.12 (0–0.4) | 0.14 (0–1.05) | 0.73 |
| SIRI | 0.90 (0.2–6.12) | 1.22 (0.19–20.13) | 0.02 |
| NLR | 1.76 (0.3–11.7) | 2.34 (0.6–49.6) | 0.02 |
| PLR | 129.18 (59.8–427.7) | 125.49 (0.14–833.3) | 0.88 |
| LMR | 4.02 (1.66–9.05) | 3.81 (0.31–24.7) | 0.83 |
| ELR | 0.05 (0–0.24) | 0.06 (0–0.74) | 0.79 |
| ENLR | 0.22 (0–1.29) | 0.33 (0–6.4) | 0.08 |
| CAR | 0.18 (0–2.73) | 0.54 (0–102.2) | 0.02 |
| SII | 479.41 (55.5–5441.3) | 596.57 (8.9–8266.6) | 0.02 |
| MLR | 0.25 (0.11–0.6) | 0.26 (0.4–3.25) | 0.83 |
| AISI | 228.92 (36.6–2829.4) | 326.65 (9.07–10811.93) | 0.08 |
AISI, aggregate index of systemic inflammation; AUC, area under the curve; CAR, C-reactive protein albumin ratio; CALPRO, calprotectin; CI, confidence interval; CRP, C-reactive protein; ELR, eosinophil-to-lymphocytes ratio; ENLR, eosinophil and neutrophil-to-lymphocytes ratio; LMR, lymphocytes-to-monocytes ratio; MLR, monocytes-to-lymphocytes ratio; NLR, neutrophil-to-lymphocytes ratio; PLR, platelets-to-lymphocytes ratio; SII, systemic immune inflammation index; SIRI: Systemic inflammation response index.
a
P < 0.05 was considered statistically significant.