Table 2.
Baseline characteristics patients of with or without RAS inhibitors.
| All patients (N = 12,200) | With RAS inhibitors (N = 9729) | Without RAS inhibitors (N = 2471) | P value | |
|---|---|---|---|---|
| Age (yr) | 63.6 ± 12.6 | 63.4 ± 12.5 | 64.3 ± 12.8 | .001 |
| Male | 9067 (74.3) | 7240 (74.4) | 1827 (73.9) | .625 |
| Body mass index (kg/m2) | 24.05 ± 3.31 | 24.14 ± 3.30 | 23.70 ± 3.33 | <.001 |
| Hypertension | 6156 (50.5) | 5012 (51.5) | 1144 (46.3) | <.001 |
| Diabetes mellitus | 3411 (28.0) | 2709 (27.8) | 702 (28.4) | .581 |
| Prior angina pectoris | 1159 (9.5) | 887 (9.1) | 272 (11.0) | .005 |
| Prior myocardial infarction | 934 (7.7) | 742 (7.6) | 192 (7.8) | .802 |
| Prior heart failure | 180 (1.5) | 139 (1.4) | 41 (1.7) | .403 |
| Prior stroke | 795 (6.5) | 622 (6.4) | 173 (7.0) | .273 |
| Current smoker | 4849 (39.7) | 3921 (40.3) | 928 (37.6) | .013 |
| Killip class ≥ II | 2436 (20.0) | 1889 (19.4) | 547 (22.1) | .003 |
| eGFR < 60 mL/min/1.73m2 | 2217 (18.2) | 1674 (17.2) | 543 (22.0) | <.001 |
| Left ventricular EF (%) | 52.2 ± 11.0 | 52.2 ± 10.9 | 52.1 ± 11.4 | .568 |
| STEMI | 5806 (47.6) | 4716 (48.5) | 1090 (44.1) | <.001 |
| Coronary reperfusion* | 11,661 (95.6) | 9365 (96.3) | 2296 (92.9) | <.001 |
| Medications at discharge | ||||
| Aspirin | 12,160 (99.7) | 9714 (99.8) | 2446 (99.0) | <.001 |
| P2Y12 inhibitor | 11,666 (95.6) | 9437 (97.0) | 2229 (90.2) | <.001 |
| Beta-blockers | 10,251 (84.0) | 8663 (89.0) | 1588 (64.3) | <.001 |
| Statins | 11,415 (93.6) | 9232 (94.9) | 2183 (88.3) | <.001 |
Values are mean ± standard deviation or number (%).
Abbreviations: EF = ejection fraction, eGFR = estimated glomerular filtration rate, RAS = renin-angiotensin system, STEMI = ST-elevation myocardial infarction.
*
Included reperfusion by percutaneous coronary intervention, thrombolysis, or coronary artery bypass graft, myocardial infarction with non-obstructed coronary arteries and myocardial bridge.