Table 4.
Multivariate cox-proportional hazard analysis of 3-yr events, based on beta-blocker prescription at discharge (N = 12,200).
| Events | With beta-blockers (N = 10,251) | Without beat-blockers (N = 1949) | Hazard ratio* (95% CI) | P value |
|---|---|---|---|---|
| No. of patients with events (rate per 100 patient-year†) | ||||
| Cardiac death | 483 (1.8) | 162 (3.3) | 0.78 (0.64–0.94) | .010 |
| All-cause death | 787 (2.9) | 249 (5.0) | 0.79 (0.68–0.93) | .003 |
| MI | 334 (1.2) | 63 (1.3) | 1.06 (0.79–1.41) | .712 |
| Revascularization | 891 (3.4) | 155 (3.3) | 0.99 (0.83–1.19) | .920 |
| Heart failure‡ | 358 (1.3) | 102 (2.1) | 0.82 (0.65–1.03) | .089 |
| MACE | 1620 (6.4) | 388 (8.6) | 0.87 (0.77–0.97) | .017 |
| Stroke | 213 (0.8) | 40 (0.8) | 1.05 (0.73–1.50) | .800 |
| MACCE | 1786 (7.1) | 418 (9.3) | 0.89 (0.79–0.99) | .035 |
| NCD | 305 (1.1) | 87 (1.8) | 0.83 (0.64–1.07) | .151 |
| MACE with NCD | 1883 (7.4) | 458 (10.1) | 0.87 (0.78–0.97) | .010 |
Abbreviations: CI = confidence interval, MACCE = major adverse cardiocerebral event, MACE = major adverse cardiac event, MI = myocardial infarction, NCD = noncardiac death.
Adjusted for age, sex, body mass index, hypertension, diabetes mellitus, prior angina, prior MI, prior heart failure, current smoker status, Killip class, estimated glomerular filtration rate, left ventricular ejection fraction, type of myocardial infarction, coronary reperfusion, and medications at discharge (aspirin, P2Y12 inhibitors, inhibitors of the renin-angiotensin system, and statins).
Unadjusted event rate.
Re-hospitalization due to heart failure.