FIGURE 1.

Family pedigrees and liver histopathology. (A) Pedigrees of 3 families identified with identified recessive inherited mutations in transient receptor potential cation channel subfamily M member 7 (TRPM7). (B) Hematoxylin-eosin staining of liver biopsies from individuals 3, 4, and 5 (I3, I4, and I5), showing micronodular cirrhosis, canalicular, and hepatocellular cholestasis in I3; parenchymal damage, bridging collapse, and severe cholestasis in I4; low hepatic damage and chronic cholestasis with portal and septal fibrosis in I5. The scale bar is 500 µm.