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. 2024 Nov 29;8(12):e0598. doi: 10.1097/HC9.0000000000000598

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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TRPM7 protein structure. The protein comprises 4 melastatin homologous regions in the N-terminal domain and 6 transmembrane segments with a pore region located between segments 5 and 6. The C-terminal domain consists of the transient receptor potential region, followed by the connecting loop of the coiled-coil domain and the serine/threonine protein kinase domain, which is able to phosphorylate substrates and regulate the activity of downstream target proteins.^30,31 Abbreviations: MHR, melastatin homologous regions; TRP, transient receptor potential.