TABLE 2.

Combination treatment of minoxidil with PRP, LLLT and microneedling.

Authors	Experimental design	Number of patients	Experimental groups	Results	Adverse effects
Alves and Grimalt 30	Split scalp study comparing 5% topical minoxidil versus PRP injection	13	Minoxidil monotherapy versus minoxidil + PRP	Combination therapy led to a notable rise in hair density and average hair count in comparison to using minoxidil alone. Small sample size and limited follow‐up (6 months)	Not specified
Pakhomova and Smirnova 31	Three‐arm study comparing topical minoxidil 5% with PRP	69	Topical minoxidil monotherapy versus PRP monotherapy versus combination therapy	Combination therapy significantly outperformed PRP monotherapy, nearly tripling overall hair density, with similar synergistic benefits observed in other studies	Not specified
Gentile et al. 32	Comparison of LLLT with PRP and microneedling	23	LLLT + PRP + microneedling	Combined treatment increased mean hair density at 58 weeks for all patients compared to baseline, proving effective and safe despite the absence of a control group	Not specified
Shah et al. 33	Comparison of PRP with microneedling and minoxidil	50	Topical minoxidil monotherapy versus PRP + microneedling	Combination therapy resulted in the highest satisfaction and improvement ratings from both patients and clinicians	Not specified
Yepuri and Venkataram 34	Trial of PRP and microneedling combination therapy	60	PRP + microneedling	Over 80% of participants experienced at least 40% improvement in hair growth after four sessions	Not specified
Jha et al. 35	Retrospective study evaluating minoxidil, PRP, and microneedling	93	Topical minoxidil monotherapy versus PRP + topical minoxidil versus PRP + topical minoxidil + microneedling	Triple combination therapy showed the greatest terminal to vellus hair ratio, the highest number of negative hair pull tests, and the most significant improvement in hair growth	Not specified

Abbreviations: LLLT, low‐level laser therapy; PRP, platelet‐rich plasma.