TABLE 6.

Predicted ADMET properties of 5 key active compounds.

Compounds	Absorption	Distribution	Metabolism										Excretion	Toxicity
	Pgp-substrate	BBB Penetration	CYP1A2		CYP2C19		CYP2C9		CYP2D6		CYP3A4		CL	Rat oral acute toxicity	Liver injury
			Inhibitor	Substrate	Inhibitor	Substrate	Inhibitor	Substrate	Inhibitor	Substrate	Inhibitor	Substrate
Torachrysone	No	No	Yes	Yes	Yes	No	Yes	Yes	Yes	No	Yes	No	Moderate	No	Yes
Hydroxyemodin	No	No	Yes	No	Yes	No	No	Yes	Yes	No	No	No	Moderate	No	Yes
6-Methylrhein	No	No	No	No	No	No	No	Yes	No	No	No	No	Low	No	Yes
Rhein	No	No	No	No	No	No	No	Yes	No	No	No	No	Low	No	Yes
Emodin anthrone	No	No	Yes	No	Yes	No	Yes	Yes	Yes	No	Yes	No	Moderate	No	Yes