Table 2.

Pro- and anti-oxidative effects of different GPR55 ligands.

Compound	Observed effects
Agonists	Upregulated	Unchanged	Downregulated	Study
Anandamide			NOS2 expression, NO production	[72]
AM251			NOS2 expression	[72]
O-1602			NO production	[69, 70]
	SOD, GSH, Catalase		Malondialdehyde	[84, 85]
	SOD activity		Malondialdehyde	[86]
LPI			iNOS synthesis, NO production, ROS production	[69]
			ROS production	[116]
DHA-DA	nNOS expression, NO synthesis, ROS production	eNOS, iNOS		[97]
Antagonists
CID-16020046			NOS2 expression, NO production	[72]
			NOX4 expression & synthesis, ROS production	[117]
	Nrf2		ROS production	[100]
KIT C, KIT H	Nrf2		8-iso-PGF2α production, oxidative cell death	[58]