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. 2024 Nov 19;7:45. doi: 10.20517/cdr.2024.131

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© The Author(s) 2024.

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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ACC1 and FASN as potential therapeutic targets for overcoming treatment resistance. A simplified representation of Fa synthesis provides phospholipids for the cell membrane. ACC1 is a critical enzyme in the carboxylation of acetyl-CoA to malonyl-CoA. Malonyl-CoA is then converted by FASN to palmitate, a saturated FA. Palmitate undergoes additional modifications, resulting in the production of SFA and MUFA. ACC1: Acetyl-CoA carboxylase 1; FASN: fatty acid synthase; FA: fatty acid; HER2: epidermal growth factor receptor 2; MHC-I: major histocompatibility complex class I.