Table 1.
Characteristics of the Study Sample and the comparison between Study sample and out-of-sample Parent population-based CoLaus|PsyCoLaus cohort using two-sample Kolmogorov-Smirnoff statistical distribution test (for continuous variables).
| Variables | Study sample (n = 864) | CoLaus|PsyCoLaus (Parent sample) (n = 4881) |
Out-of-sample Parent (n = 4017) | KS statistic | p-value KS test |
|---|---|---|---|---|---|
| Sex (% female) | 48.7 | 55.1 | 56.4 | – | – |
| Age (year), mean ± SD | 61.93 ± 9.8 | 62.93 ± 10.45 | 63.55 ± 10.63 | 0.10 | <0.001 |
| Fatigue severity scale score (FSS), mean ± SD | 2.80 ± 1.38 | 2.88 ± 1.46 (n = 3231) | 2.90 ± 1.48 (n = 2367) | 0.40 | <0.001 |
| EBV seropositive, % | 96.8 | 96.8 (n = 3820) | 96.8 (n = 2956) | – | – |
| EBNA-1 IgG level (MFI), mean ± SD | 5120 ± 3277 | 5100 ± 3402 (n = 3820) | 5095.35 ± 3438 (n = 2956) | 0.03 | 0.59 |
| VCA p18 IgG level (MFI), mean ± SD | 7333 ± 3426 | 7573 ± 3404 (n = 3820) | 7644 ± 3395 (n = 2956) | 0.04 | 0.18 |
| CVR: SCORE2 % estimation of CVD event, mean ± SD | 6.65 ± 0.48 (n = 844) | 7.56 ± 0.57 (n = 4180) | 7.83 ± 0.58 (n = 3336) | 0.20 | <0.001 |
| Insomnia severity index (ISI), mean ± SD | 0.22 ± 0.53 (n = 813) | 0.24 ± 0.56 (n = 3437) | 0.24 ± 0.56 (n = 2624) | 0.29 | <0.001 |
| Berlin Score (OSA), mean ± SD | 0.83 ± 0.80 (n = 863) | 0.80 ± 0.76 (n = 4647) | 0.79 ± 0.75 (n = 3784) | 0.06 | 0.019 |
| Depression (% depressed) | 48.4 (n = 858) | 49.12 (n = 3583) | 49.36 (n = 2725) | – | – |
Key: EBV: Epstein-Barr virus, CVR: cardio-vascular risk, EBNA-1: Epstein Barr, EBNA-1: EBNA nuclear antigen-1, VCA p18: viral capsid antigen p18, IgG: immunoglobulin G levels, MFI: median fluorescent intensity threshold, CVR: cardiovascular risk SCORE2 percentage, CVD: cardiovascular disorder, ISI: Insomnia Severity Index, OSA: obstructive sleep apnoea Berlin score, SD: standard deviation.