Fig. 2.

a – ROC curve showing the optional cut-off point of IGF-1 based on survival. b – The histogram represents the distribution of IGF-1 levels across individual cases, with the dashed line indicating the established cutoff point at 62.4 ng/ml. Cases are ordered from lowest to highest expression levels of IGF-1. Red bars signify cases that passed away. c and d: Kaplan Meier curves show the difference for overall survival (OS), and progression-free survival (PFS), respectively, between low and high IGF-1 expression, * p-value < 0.05: statistically significant, Cox-regression. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)