Table 2.
Participant ID | Diagnosis date time framea | SARS-CoV-2 therapies administered during the same hospitalization | Clinical course | Days to negative SARS-CoV-2 PCR from infusion | Days to discharge from infusion | Change in pulmonary radiographic findings |
---|---|---|---|---|---|---|
DVX201-001 | 9/2021–11/2021 | remdesivir, dexamethasone | discharged home without complications | 7 | 1 | post-imaging not performed |
DVX201-002 | 10/2021–12/2021 | remdesivir, casirivimab and imdevimab (Regeneron), dexamethasone | started chemotherapy 5 days after infusion and discharged; readmitted for hypoxemic respiratory failure attributed to persistent COVID-19 | 53 | 13 | improvement with subsequent worsening |
DVX201-003 | 10/2021–12/2021 | remdesivir, dexamethasone | discharged home without complications | 7 | 1 | improved |
DVX201-004 | 11/2021–1/2022 | remdesivir, dexamethasone | improved and discharged home off oxygen | N/Ab | 3 | post-imaging not performed |
DVX201-006 | 1/2022–3/2022 | remdesivir, dexamethasone | improved and discharged home off oxygen | 0 | 2 | post-imaging not performed |
DVX201-007 | 1/2022–3/2022 | remdesivir, dexamethasone | improved and discharged home off oxygen but with residual dyspnea with exertion | 1 | 6 | improved |
DVX201-008 | 3/2022–5/2022 | remdesivir, dexamethasone, nirmatrelvir-ritonavir | improved and discharged on 2 L oxygen; readmitted with persistent COVID-19 | 24 | 2 | improvement with subsequent worsening |
DVX201-009 | 3/2022–5/2022 | remdesivir, dexamethasone | discharged home without complications | N/Ac | 1 | post-imaging not performed |
DVX201-010 | 5/2022–7/2022 | remdesivir | improved and discharged home | 27 | 8 | post-imaging not performed |
General time periods are provided to protect participant privacy.
Last positive test was on day 14 and indeterminate; participant refused subsequent testing.
Only positive from bronchoalveolar lavage prior to enrollment and not retested. Nasopharyngeal swabs were negative.