TABLE 1.
TTV and HCV detection and loads in the plasma of 25 doubly infected patients at selected times of IFN treatment
| Day of treatment | TTV
|
HCV
|
||||
|---|---|---|---|---|---|---|
| No. positive/tested (%)a | Loadb
|
No. positive/tested (%)a | Loadb
|
|||
| Mean ± SE | Rangec | Mean ± SE | Rangec | |||
| 0 | 25/25 (100) | 6.7 ± 0.2 | 4.9–9.3 | 25/25 (100) | 6.0 ± 0.2 | 4.7–7.4 |
| 1 | 25/25 (100) | 6.7 ± 0.2 | 4.9–10.3 | 22/23 (96) | 5.2 ± 0.2∗∗ | 3.4–6.3 |
| 2 | 18/18 (100) | 6.8 ± 0.2 | 5.6–9.4 | 12/15 (80) | 5.0 ± 0.3∗∗ | 3.7–6.6 |
| 3 | 12/12 (100) | 5.9 ± 0.3* | 3.1–7.1 | 15/17 (88) | 5.2 ± 0.2** | 4.9–6.7 |
| 7 | 13/14 (93) | 5.5 ± 0.3** | 3.3–7.1 | 14/16 (87) | 5.1 ± 0.3*** | 4.8–6.6 |
| 14 | 14/19 (74) | 5.4 ± 0.4** | 5.2–8.6 | 17/20 (85) | 4.5 ± 0.2*** | 3.3–6.7 |
| 30 | 6/14 (43) | 3.8 ± 0.3*** | 3.6–7.0 | 10/18 (55) | 4.3 ± 0.3*** | 5.3–6.2 |
| 90 | 7/17 (41) | 4.1 ± 0.4*** | 3.5–7.6 | 6/18 (33) | 4.2 ± 0.4*** | 5.3–7.1 |
a
Not all samples were available for all patients at all times.
b
Log10 copies of viral genome per milliliter of plasma. Viral loads below the detection assay sensitivity were arbitrarily scored as 3 log10 for calculation. *, **, ***, significantly different from day 0 at P < 0.05, P < 0.01, and P < 0.001, respectively (Student's t test).
c
Positive patients only.