TABLE 3.
TTV and HCV dynamics in doubly infected patients treated with IFN
| Virus | Effectiveness of drug ɛ (mean ± SE) | Viral parameter (mean ± SE)
|
|||
|---|---|---|---|---|---|
| Delay of drug response (t0 [days]) | Clearance rate (c [days−1]) | Virion half-life (t1/2 [days])a | Minimal input and clearance of plasma virions/day (1010)b | ||
| TTV | 0.94 ± 0.002 | 2.07 ± 0.004 | 2.5 ± 3.1 | 0.27 ± 0.31 | 3.8 ± 0.6 |
| HCV | 0.85 ± 0.002 | <1 | 5.0 ± 4.1 | 0.14 ± 0.03 | 2.7 ± 0.4 |
a
Calculated by the equation t1/2 = ln (2)/c.
b
Calculated by the equation P = cV0, assuming that plasma and extracellular fluids were 3.0 × 103 ml in total and in equilibrium. In this equation P represents daily production of virions in plasma.