Table 1.
Clinical characteristics of the study cohort.
| Parameter | Total N = 87 |
DIC n = 35 | No DIC n = 52 |
|---|---|---|---|
| Age (y) | 63 (53-73) | 58 (50-70) | 64 (55-75) |
| Sex, female | 38 (44) | 11 (31) | 27 (52) |
| Race | |||
| Caucasian | 86 (99) | 35 (100) | 51 (98) |
| Black | 1 (1) | 0 (0) | 1 (2) |
| SIC at admission | 56 (64) | 35 (100) | 21 (40) |
| ISTH overt DIC score | 4 (3-5) | 5 (5-6) | 3 (2-4) |
| SIC score | 4 (3-5) | 5 (5-6) | 3 (2-4) |
| SOFA score | 12 (7-14) | 13 (12-15) | 9 (6-12) |
| SAPS II score | 52 (39-66) | 64 (42-75) | 50 (37-63) |
| 7-d mortality | 15 (17) | 13 (37) | 2 (4) |
| 28-d mortality | 25 (29) | 17 (49) | 8 (15) |
| Septic shock | 66 (76) | 30 (86) | 36 (69) |
| Focus of infection | |||
| Pneumonia | 37 (43) | 13 (37) | 24 (46) |
| UTI | 12 (14) | 2 (6) | 10 (19) |
| Multiple foci | 12 (14) | 8 (23) | 4 (8) |
| Bacteremia | 55 (63) | 26 (74) | 29 (56) |
| Gram-negative | 33 (38) | 18 (51) | 15 (29) |
| Gram-positive | 22 (25) | 8 (23) | 14 (27) |
| Fungaemia | 8 (9) | 4 (11) | 4 (8) |
| Systemic candidiasis | 4 (5) | 2 (6) | 2 (4) |
| Invasive aspergillosis | 6 (7) | 2 (6) | 4 (8) |
| Viremia | 14 (16) | 6 (17) | 8 (15) |
| CMV | 5 (6) | 2 (6) | 3 (6) |
| Influenza A/B | 3 (3) | 1 (3) | 2 (4) |
| Cirrhosis hepatitis | 8 (9) | 5 (14) | 3 (6) |
| Chronic kidney disease | 16 (18) | 5 (14) | 11 (21) |
| AKI at admission | 44 (51) | 21 (60) | 23 (44) |
| Renal-replacement therapy | 28 (32) | 15 (43) | 13 (25) |
| Mechanical ventilationa | 37 (43) | 17 (49) | 20 (38) |
| Haemato-oncologic disease | 20 (23) | 11 (31) | 9 (17) |
| AML | 7 (8) | 7 (20) | 0 (0) |
| ALL | 5 (6) | 4 (11) | 1 (2) |
| Subacute | 8 (9) | 0 (0) | 8 (15) |
| Status posttransplantation | 12 (14) | 5 (14) | 7 (13) |
| Liver transplantation | 6 (7) | 2 (6) | 4 (8) |
Displayed are the median with IQR and n (%).
AKI, acute kidney injury; ALL, acute lymphoytic leukemia; AML, acute myeloid leukemia; CMV, cytomegalia virus; DIC, disseminated intravascular coagulopathy; ISTH, International Society on Thrombosis and Haemostasis; SAPS, Simplified Acute Physiology Score; SIC, sepsis-induced coagulopathy; SOFA, Sequential Organ Failure Assessment; UTI, urinary tract infection.
a
Includes patients with non-invasive ventilation and intubated patients.