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. 2024 Sep 26;8(11):104462. doi: 10.1016/j.cdnut.2024.104462

FIGURE 2.

FIGURE 2

Exploration of significant metabolite-diet associations within and across each of the Healthy Eating Index 2015 (HEI-2015), the Dietary Approaches to Stop Hypertension (DASH), and a Mediterranean-style diet (AMED). (A) Associations with each of the 3 diet patterns for all metabolites showing ≥1 significant association with ≥1 diet pattern in a metabolome-wide association study (P < 1.7∗10–5 after a Bonferroni correction based on the effective number of independent tests). Note: + denotes significant associations (P < 1.7∗10–5). (B) Venn diagram of the number of significant associations (P < 1.7∗10–5 after a Bonferroni correction based on the effective number of independent tests) within and across metabolome-wide association studies for each of the 3 diet patterns. (C) A breakdown of the metabolite class membership accounting for each significant diet-metabolite association (P < 1.7∗10–5 after a Bonferroni correction based on the effective number of independent tests), arising from metabolome-wide association studies with each of the 3 diet patterns.