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Evaluation of myocardial tissue enrichment and drug release in heart transplantation model by drug-loaded microvesicle combined with UTMD local administration. (A) EB content in transplanted heart tissues under different ultrasonic irradiation; (B) Distribution of SIR in various organs; (C) Fluorescence intensity of different group at 360 min; sirolimus concentration in (D) cardiac tissue of transplanted heart and (E) peripheral blood. *,**,***P < 0.05, 0.01 and 0.001, n = 10.
