. 2024 Nov 14;15:1483856. doi: 10.3389/fphar.2024.1483856

TABLE 4.

Target gene expression profile in DU-145 cells treated with the selected plant extracts.

Treatment	RQ values of target genes
Treatment	Ar	bcl ₂	caspase 3	cdk-1	p53
VD-DCM	1.23 ± 0.00^b	3.10 ± 0.00^a	0.95 ± 0.00^b	0.63 ± 0.000^c	0.76 ± 0.00^c
VD-EA	1.50 ± 0.00^a	1.09 ± 0.00^b	0.79 ± 0.00^c	0.86 ± 0.000^b	0.92 ± 0.00^b
Ctrl	1.00 ± 0.00^c	1.00 ± 0.00^c	1.00 ± 0.00^a	1.00 ± 0.000^a	1.00 ± 0.00^a

The results are presented as $\bar{x} \pm S D$ for three replicate experiments. Means with different superscript letters within the same column are significantly different (P< 0.001; One-Way ANOVA with Tukey’s post hoc test); VD-DCM: Dichloromethane leaf extract of Vitex doniana (287.01 μg/mL); VD-EA: Ethyl acetate leaf extract of Vitex doniana (38.68 μg/mL); Ctrl: Control/Untreated; ar: Androgen receptor gene; bcl ₂: B-cell lymphoma 2 gene; caspase 3: Cysteine-aspartic acid protease gene; cdk-1: Cyclin-dependent Kinase 1/Cell division cycle protein 2 gene; p53: Tumour Protein 53 gene.