TABLE 3.
Multivariable regression for outcome of excellent clinical outcome at 90 days (modified Rankin Scale score 0–1) in patients with successfully reperfused acute ischemic stroke due to anterior circulation large‐vessel occlusion.
| Variable | mRS2‐6 | mRS0‐1 | Univariable Model | Multivariable Model | ||
|---|---|---|---|---|---|---|
| N = 66 | N = 38 | OR (95% CI) | p | OR (95% CI) | p value | |
| Age, median (IQR) | 72 (64, 82) | 67 (53, 74) | 0.97 (0.95 to 1.00) | 0.054 | 0.98 (0.94 to 1.01) | 0.19 |
| Sex, n (%) | ||||||
| Female | 37 (56) | 21 (55) | — | |||
| Male | 29 (44) | 17 (45) | 1.03 (0.46 to 2.31) | 0.94 | ||
| Occlusion segment, n (%) | ||||||
| ICA | 5 (7.6) | 3 (7.9) | — | |||
| M1 | 49 (74) | 27 (71) | 0.92 (0.21 to 4.75) | 0.91 | ||
| Poximal‐M2 | 12 (18) | 8 (21) | 1.11 (0.21 to 6.67) | 0.9 | ||
| Smoking status, n (%) | 34 (52) | 20 (53) | 1.01 (0.45 to 2.27) | 0.97 | ||
| Alcohol use, n (%) | 18 (28) | 14 (37) | 1.52 (0.64 to 3.59) | 0.33 | ||
| Hypertension, n (%) | 57 (86) | 26 (68) | 0.34 (0.12 to 0.91) | 0.032 | 0.53 (0.15 to 1.89) | 0.33 |
| Dyslipidemia, n (%) | 35 (53) | 20 (53) | 0.98 (0.44 to 2.20) | 0.97 | ||
| Diabetes, n (%) | 22 (33) | 7 (18) | 0.45 (0.16 to 1.14) | 0.11 | ||
| Heart disease, n (%) | 34 (52) | 18 (47) | 0.85 (0.38 to 1.88) | 0.68 | ||
| Atrial fibrillation, n (%) | 26 (39) | 18 (47) | 1.38 (0.62 to 3.11) | 0.43 | ||
| History of stroke/TIA, n (%) | 11 (17) | 6 (16) | 0.94 (0.30 to 2.71) | 0.91 | ||
| Chronic kidney disease, n (%) | 11 (17) | 9 (24) | 1.55 (0.57 to 4.18) | 0.38 | 0.89 (0.22 to 3.46) | 0.87 |
| Sleep apnea, n (%) | 6 (9.1) | 5 (13) | 1.52 (0.41 to 5.40) | 0.52 | ||
| Admission NIHSS score, median (IQR) | 17 (13, 20) | 12 (8, 14) | 0.84 (0.76 to 0.91) | <0.001 | 0.83 (0.73 to 0.92) | 0.001 |
| Premorbid mRS score, n (%) | ||||||
| 0 | 54 (82) | 29 (78) | — | |||
| 1 | 12 (18) | 8 (22) | 1.24 (0.44 to 3.35) | 0.67 | ||
| Occlusion laterality, n (%) | ||||||
| Left | 29 (49) | 16 (52) | — | |||
| Right | 30 (51) | 15 (48) | 0.91 (0.38 to 2.17) | 0.82 | ||
| ASPECTS, median (IQR) | 9.00 (7.00, 10.00) | 10.00 (8.00, 10.00) | 1.15 (0.93 to 1.48) | 0.23 | ||
| rCBF <20% volume, median (IQR), mL | 0 (0, 11) | 0 (0, 5) | 0.97 (0.93 to 1.00) | 0.1 | 0.97 (0.91 to 1.03) | 0.38 |
| Tmax >6 s volume, median (IQR), mL | 119 (76, 167) | 104 (66, 141) | 1.00 (0.99 to 1.00) | 0.18 | 1.00 (0.99 to 1.01) | 0.47 |
| Mismatch ratio, median (IQR) | 3.8 (2.8, 7.1) | 4.9 (3.0, 8.7) | 1.06 (0.98 to 1.18) | 0.17 | ||
| Hypoperfusion intensity ratio, median (IQR) | 0.40 (0.20, 0.60) | 0.40 (0.20, 0.50) | 0.36 (0.06 to 2.21) | 0.27 | ||
| CBV index, median (IQR) | 0.80 (0.70, 0.90) | 0.80 (0.73, 0.90) | 5.78 (0.39 to 98.6) | 0.21 | ||
| PVT, n (%) | 26 (39) | 4 (11) | 0.18 (0.05 to 0.52) | 0.004 | 0.11 (0.02 to 0.48) | 0.006 |
| Tan score (0–3), median (IQR) | 2.00 (1.00, 2.00) | 2.00 (1.00, 2.00) | 1.04 (0.64 to 1.70) | 0.87 | 0.50 (0.21 to 1.12) | 0.1 |
| IVT administered, n (%) | 19 (29) | 13 (34) | 1.29 (0.54 to 3.02) | 0.56 | 0.83 (0.24 to 2.69) | 0.75 |
| MT attempted, n (%) | 66 (100) | 38 (100) | ||||
| Symptom onset to door time, median (IQR), min | 75 (31, 135) | 66 (49, 125) | 1.00 (1.00 to 1.00) | 0.74 | ||
| Door to CT time, median (IQR), min | 31 (22, 54) | 31 (17, 60) | 1.00 (1.00 to 1.01) | 0.39 | ||
| Door to needle time, median (IQR), min | 59 (40, 76) | 68 (47, 93) | 1.00 (1.00 to 1.00) | 0.98 | ||
| Door to groin puncture time, median (IQR), min | 144 (118, 203) | 183 (141, 272) | 1.01 (1.00 to 1.01) | 0.14 | ||
| Door to recanalization time, median (IQR), min | 277 (186, 332) | 275 (224, 533) | 1.00 (1.00 to 1.00) | 0.76 | ||
| Groin puncture to recanalization time, median (IQR), min | 30 (24, 39) | 25 (22, 33) | 1.01 (0.99 to 1.04) | 0.47 | ||
| mTICI score, n (%) | ||||||
| 2b | 24 (36) | 6 (16) | — | — | ||
| 2c | 11 (17) | 9 (24) | 3.27 (0.95 to 12.1) | 0.064 | 4.71 (0.85 to 29.7) | 0.083 |
| 3 | 31 (47) | 23 (61) | 2.97 (1.09 to 9.07) | 0.041 | 3.40 (0.96 to 13.8) | 0.068 |
Abbreviations: ASPECTS, Alberta Stroke Program Early Computed Tomograpy Score; CBV, Cerebral Blood Volume; CT, computed tomograpy; ICA, internal carotid artery; IQR, interquartile range; IVT, intravenous thrombolysis; mRS, modified Rankin Scale; MT, mechanical thrombectomy; mTICI, modified Thrombolysis in Cerebral Infarction; NIHSS, National Institutes of Health Stroke Scale; PVT, prolonged venous transit; rCBF, relative cerebral blood flow; TIA, transient ischemic attack.