Table 4:

TRL Definitions defined by the HORIZON 2020 - Work Programme 2014-2015 and the scoping review abstraction of the HORIZON 2020 definitions.

TRL	Definition	Scoping Review E[]planation	Count
1	Basic principle observed	The idea has been formulated, proof of concept only	0
2	Technology concept formulated	A software prototype has been made and tested virtually	0
3	Experimental proof of concept	Analytical studies and feasibility studies. The device must be built	17
4	Technology validated in the lab	The device has been tested on non-human or one healthy case study for validation.	26
5	Technology validated in the relevant environment validation.	The device has been tested on healthy participants	21
6	Technology demonstrated in the relevant environment	The device has been tested on a target population in a clinical setting (ISO Standard not complete)	29
7	System prototype demonstration in an operational environment	The device has been tested for its intended purpose in an operational environment (outside of the clinic and lab) ISO Standards should be complete	14
8	System complete and qualified	The device is ready to be commercialized and has been validated	1
9	Actual system is proven in an operational environment	The device is available in the market	27