TABLE 2.
Anthropometrics, comorbidities and obstructive sleep apnoea (OSA) severity in the hypoxia-inducible factor-1α (HIF-1α) concentration cohort
| Full cohort (n=53) | Placebo (n=22) | STM 200 mg (n=7) | STM 400 mg (n=24) | |
|---|---|---|---|---|
| Anthropometrics | ||||
| Sex | ||||
| Male | 38 (72) | 17 (77) | 4 (57) | 17 (71) |
| Female | 15 (28) | 5 (23) | 3 (43) | 7 (29) |
| Age (years) | 60±10 | 61±10 | 60±11 | 60±9 |
| Weight (kg) | 85±13 | 89±12 | 83±12 | 82±14 |
| BMI (kg·m−2) | 28±3 | 29±3 | 29±3 | 26±3 |
| Waist/hip ratio | 1 (0.9–1) | 1 (0.9–1) | 1 (0.9–1) | 1 (0.9–1) |
| Comorbidities | ||||
| Hypertension | 20 (38) | 6 (27) | 5 (71) | 9 (38) |
| Systolic blood pressure (mmHg) | 133±13 | 134±11 | 134±12 | 131±14 |
| Diastolic blood pressure (mmHg) | 82±9 | 81±6 | 87±8 | 80±11 |
| Diabetes mellitus type 2 | 3 (6) | 2 (9) | 0 | 1 (4) |
| Hyperlipidaemia | 5 (9) | 3 (14) | 0 | 2 (8) |
| OSA | ||||
| AHI (events·h−1) including range | 55±23 (15–109) | 54±21 (19–91) | 64±30 (15–109) | 54±22 (22–92) |
| ODI (events·h−1) | 35±22 | 35±21 | 41±29 | 33±20 |
| Mean oxygen saturation (%) | 93±2 | 93±2 | 92±2 | 94±2 |
| Time in <90% oxygen saturation (% TST) | 11±14 | 12±17 | 19±14 | 6±10 |
| Minimum oxygen saturation (%) | 78±8 | 79±8 | 72±8 | 80±6 |
| HIF-1α concentration (ng·mL−1) | 9.4 (8.1–9.9) | 9.4 (8.1–9.7) | 11.3 (10–18.3) | 9 (8–9.7) |
Data are presented as n (%), mean±sd or median (interquartile range), unless otherwise stated. BMI: body mass index; AHI: apnoea–hypopnoea index; ODI: oxygen desaturation index; TST: total sleep time.