Table 3.
Predictors of the cardiovascular events based on univariate and multivariate cox regression analysis.
| Variables | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| β | p value | HR (95%CI) | β | p value | HR (95%CI) | |
| Age (per year) | 0.041 | 0.025 | 1.042 (1.005–1.081) | |||
| Sex | ||||||
| Female | Ref | – | – | |||
| Male | 0.043 | 0.927 | 1.043 (0.411–2.653) | |||
| Duration of PD, months | 0.003 | 0.629 | 1.003 (0.990–1.017) | |||
| Diabetes | ||||||
| No | Ref | – | – | |||
| Yes | 1.010 | 0.041 | 2.745 (1.043–7.225) | |||
| Cardiovascular disease | ||||||
| No | Ref | – | – | |||
| Yes | 0.370 | 0.453 | 1.448 (0.550–3.809) | |||
| ARNI | ||||||
| No | Ref | – | – | |||
| Yes | −0.698 | 0.157 | 0.498 (0.189–1.309) | 2.942 | 0.010 | 0.053 (0.006–0.492) |
| Hemoglobin, g/L | −0.013 | 0.298 | 0.987 (0.964–1.011) | |||
| iPTH, pmol/L | 0.001 | 0.072 | 1.00 (1.000–1.003) | |||
| Alb, g/L | 0.012 | 0.784 | 1.012 (0.928–1.104) | |||
| Scr, μmol/L | −0.001 | 0.194 | 0.999 (0.997–1.001) | |||
| BUN, mmol/L | −0.042 | 0.262 | 0.959 (0.892–1.032) | |||
| SUA, μmol/L | 0.001 | 0.728 | 1.001 (0.996–1.006) | |||
| TC, mmol/L | −0.011 | 0.758 | 0.989 (0.923–1.061) | |||
| TG, mmol/L | −0.008 | 0.748 | 0.992 (0.945–1.041) | |||
| LDL-cholesterol, mmol/L | −0.012 | 0.770 | 0.988 (0.911–1.072) | |||
| HbA1c, % | 0.214 | 0.111 | 1.239 (0.952–1.612) | |||
| NT-pro BNP, pg/mL | 0.341 | 0.107 | 1.407 (0.928–2.131) | 0.840 | 0.015 | 2.317 (1.179–4.554) |
| Total weekly PD Kt/V | 1.268 | 0.065 | 3.553 (0.922–3.685) | |||
| Total weekly renal Kt/V | −0.086 | 0.731 | 0.917 (0.561–1.499) | |||
| LVEF, mm | 0.056 | 0.168 | 1.057 (0.977–1.145) | |||
| IVS, mm | −0.232 | 0.142 | 0.793 (0.581–1.081) | |||
Bold indicates significance at p < 0.05.
Abbreviations: ARNI, angiotensin receptor-neprilysin inhibitor; PD, peritoneal dialysis; Hb, Hemoglobin; Alb, albumin; BUN, blood urea nitrogen; Scr, serum creatinine; SUA, serum uric acid; iPTH, intact parathyroid hormone; HbA1c, glycated hemoglobin A1c; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride; NT-proBNP, N-terminal pro-B-Type Natriuretic Peptide; Weekly PD Kt/V, weekly peritoneal dialysis fractional clearance index for urea; LVEF, left ventricular ejection fractions; IVS, interventricular septum; HR, hazard ratio; 95%CI, 95% confidence interval.