TABLE 1.
Antibody response against E1 protein and HCV-LPs at 21 weeks after first immunization
| Mouse group | E1 protein
|
HCV-LP titera | ||
|---|---|---|---|---|
| No. seroconverted | Titera (mean/median) | Isotype | ||
| 836 | IgG1 | — | ||
| WT | 7/14 | — | — | |
| 4,766 | IgG2a, IgG1 | 1,000 | ||
| 181 | — | |||
| — | — | |||
| — | 500 | |||
| — | — | |||
| 193 983/196 | — | |||
| 521 | IgG2a, IgG1 | — | ||
| — | 1,000 | |||
| 186 | — | |||
| 196 | — | |||
| — | — | |||
| — | — | |||
| 485 | IgG1 | — | ||
| N4 | 11/12 | 196 | 1,000 | |
| 521 | IgG1 | — | ||
| >60,000 | IgG1, IgG2a | 8,000 | ||
| 185 | — | |||
| 395 6,616/485 | 1,000 | |||
| — | 1,000 | |||
| 4,000 | IgG2a, IgG1 | 1,000 | ||
| 572 | IgG2a, IgG1 | 1,000 | ||
| 5,849 | IgG1, IgG2a | — | ||
| 412 | IgG1, IgG2a | — | ||
| 161 | — | |||
a
Titers are shown as the reciprocal of the serum dilution resulting in an OD equal to two times the mean of the background of the assay. —, nonseroconverted mouse.