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. Author manuscript; available in PMC: 2024 Dec 2.
Published in final edited form as: Adv Drug Deliv Rev. 2022 Sep 28;190:114554. doi: 10.1016/j.addr.2022.114554

Fig. 5.

Fig. 5.

a) Scheme of supramolecular hydrogels’ synthetic route and their application as controlled delivery systems for accelerated wound healing. Adamantane, which also complexes with CD but it is not photoresponsive, was used for the obtention of non-responsive control supramolecular hydrogels (EGF@S gel). b) Photographs of the reversible stiff-soft and soft-stiff state transitions of photoresponsive supramolecular hydrogels (EGF@PR-S) upon exposure to UV and visible light, respectively. c) EGF release profile of EGF@S and EGF@PR-S gels upon alternating UV and ambient visible light irradiation. d) Photographs of full thickness wounds (day 0) and further healing with different treatments (day 10). Blanck; non-treated control; EGF: EGF solution; L+: UV irradiated for 15 min. e) Schematics of acrylate-HA macromers and RGD-loaded photodegradative alkoxylphenacyl-based polycarbonate (APP) nanocarriers (purple. f) Upon UV exposure, RGD peptides (yellow) are released and covalently conjugate to acrylate groups (blue) in crosslinked HA hydrogels (white) to temporally activate αvβ3 integrins (orange) macrophage expressions, leading to macrophage polarization. a)-d) Adapted from [147], Copyright 2020, with permission from Elsevier. e)-f) Adapted with permission from [150]. Copyright 2018 Wiley.