Tzung 2008.

Methods	This was a randomised, investigator‐blinded, actively‐controlled study. It was unclear if intention‐to‐treat analysis was conducted.
Participants	Inclusion criteria of the trial A total of 40 participants of at least 20 years of age with fingernail psoriasis were allocated randomly to 2 groups (A and B) for 12 weeks of treatment. 32 participants completed the study (7 women and 25 men). 5 participants in group A and 3 in group B dropped out for reasons unrelated to the treatment.
Interventions	Group A: calcipotriol 0.005% plus betamethasone dipropionate 0.05% ointment (Daivobet®), once daily for 12 weeks Group B: calcipotriol 0.005% ointment (Daivonex), twice daily for 12 weeks
Outcomes	Outcomes of the trial NAPSI: nail matrix (4) and nail bed (4) involvement. Target nail was evaluated every 4 weeks (lower score = improvement) Investigator's Global Assessment (IGA) (0 = worse; 1 = no change; 2, 3, and 4 = slight, moderate, and marked improvement, respectively; 5 = clearance) PAGA at end of the study (0 = worse; 1 = no change; 2, 3, and 4 = slight, moderate, and marked improvement, respectively; 5 = clearance)
Notes	There were no conflicts of interest.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "...randomised trial."
Allocation concealment (selection bias)	Unclear risk	Comment: The paper provided insufficient details.
Blinding (performance bias and detection bias) Clinician/ Investigator	Low risk	Quote: "...an investigator‐blinded trial."
Blinding (performance bias and detection bias) Participants	High risk	Quote: "...an investigator‐blinded trial." Comment: The participants were not blinded to the treatment.
Blinding (performance bias and detection bias) Outcome assessor	Low risk	Quote: "...an investigator‐blinded trial." Comment: The blinded investigator was probably the assessor.
Incomplete outcome data (attrition bias) All outcomes	Low risk	40 participants were randomised; 32 participants completed the study. 5 participants in group A and 3 in group B dropped out for reasons unrelated to the treatment.
Selective reporting (reporting bias)	Low risk	All of the study's prespecified (primary and secondary) outcomes that were of interest were reported in the prespecified way.
Other bias	Low risk	This was free of other sources of bias.