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. 2024 Dec 2;19(12):e0313091. doi: 10.1371/journal.pone.0313091

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© 2024 Penman et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Concentrations of endogenous cannabinoid AEA in whole brains following vehicle or a 10 min inhalation dose of 5 mg/pad THC in FABP7^+/+ and FABP7^-/- mice. Males showed a trending effect of treatment where THC treatment reduced AEA levels regardless of genotype. Female FABP7^+/+ mice treated with THC showed trending reduction in brain AEA compared to vehicle-treated. Vehicle FABP7^-/- female mice had significantly lower brain AEA levels compared to FABP7^+/+ females. ***p<0.001 genotype effect.