Figure 2.

Ferroptosis influenced the development and suppression ratio of synoviocytes. Concentrations gradient of erastin or fer-1 were added to the cells and incubated for 48 hr. About 20 μg/L TNF-α and different concentrations of erastin or fer-1 were added in fibroblast-like synoviocytes to coculture and promoted their proliferation, and the inhibition rate of erastin or fer-1 on cells was analyzed: (a) cell viability of synoviocyte; (b) the suppression ratio of synoviocyte (⁣^∗∗P < 0.01 vs. TNF-α group, n = 3).