Figure 8.

Ferroptosis affected the growth of animals and inflammatory swelling of feet. In total, 32 male SD rats were randomly grouped into four groups: Ctrl, CIA, CIA-Erastin, and CIA-Fer1. After the success of the CIA animal model, accepting erastin or fer-1 to stimulate continuously for 5 weeks. Body weight and arthritis scores were recorded once a week. The level of paw swelling was measured by foot volume measuring instrument once a week: (a) the growth curve of rats; (b) the severity of arthritis by the arthritis score; (c) the left hind foot; (d) the right hind foot (^##P < 0.01 vs. Ctrl group and ⁣^∗∗P < 0.01 vs. CIA group, n = 8).