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. 2024 Nov 26;13:643–659. doi: 10.2147/ITT.S463556

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© 2024 Jing et al.

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MiR-1292-5p is putative target downstream of circ_0001944. (A) Circular RNA Interactome predicts that miR-1292-5p may be the target of circ_0001944. The red box was meant to highlight the Context+ score percentile. (B) SMMC7721/SOR and Huh7/SOR cells were transfected with pcDNA-hsa_circ_0001944 and miR-1292-5p mimics. The RNA expression of AGO2-RIP was detected using Real-time PCR.**P<0.01. (C) SMMC7721/SOR and Huh7/SOR cells were co-transfected with reporter construct and circ_0001944 and cel-miR-936. Renilla luciferase activity of reporter constructs (psiCHECK-1) was evaluated 48 h after transfection. **P<0.01. (D) Circ_0001944 expression is determined in SMMC7721/SOR and Huh7/SOR cells, compared to SMMC7721 and Huh7 cells respectively. **P<0.01. (E) SMMC7721/SOR and Huh7/SOR cells were transfected with Len-circ_0001944-shRNA for 24h, miR-1292-5p expression was detected using Real-time PCR assay. **P<0.01. (F) The depiction of interactive network diagram “circ_0001944-miR-1292-5p-mRNA” involved in the development of sorafenib resistance in HCC. The red box was provided to highlight the location of “circ_0001944” and “miR-1292-5p” in the“circ_0001944-miR-1292-5p-mRNA”network. For the Figure B-E, data are shown as means±SD of three independent experiments.