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. 2024 Nov 26;13:643–659. doi: 10.2147/ITT.S463556

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© 2024 Jing et al.

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Circ_0001944 advances sorafenib resistance in HCC by inhibiting ferroptosis. (A and B) SMMC7721/SOR and Huh7/SOR cells were transfected with Len-circ_0001944-shRNA, miR-1292-5p mimics, FBLN2-siRNA, miR-1292-5p inhibitor and GV657-FBLN2 for 24h, Then they were stimulated with sorafenib for another 48h. The sensitivity of these cells as shown as growth inhibition (%), was confirmed using CCK-8 assay.**P<0.01. For Figure A and B, **P<0.01 was considered to be statistically significant in Len-circ_0001944-shRNA group versus Ctrl group, in miR-1292-5p mimics group versus Crl group, in FBLN2-siRNA group versus Ctrl group, as well as in Len-circ_0001944-shRNA/miR-1292-5p inhibitor group versus Len-circ_0001944-shRNA group and in Len-circ_0001944-shRNA/GV657-FBLN2 group versus Len-circ_0001944-shRNA group. Data are shown as means±SD of three independent experiments. (C and D) SMMC7721/SOR and Huh7/SOR cells were transfected with Len-circ_0001944-shRNA.The sensitivity of these cells as shown as growth inhibition (%), was confirmed using CCK-8 assay. For Figure A and B, **P<0.01 and *P<0.05 were considered to be statistically significant in Len-circ_0001944-shRNA group versus Ctrl group, as well as in Len-circ_0001944-shRNA/Ferrostatin-1 group versus Len-circ_0001944-shRNA group. Data are shown as means±SD of three independent experiments. (E–G) Tumor-bearing mice were administrated with Len-circ_0001944-shRNA plasmid or Ferrostatin-1, and then given sorafenib (30mg/kg). Tumor presentations (E), tumor volume (F) and tumor weight (G) of each group were demonstrated. Data are representative of three independent experiments with four mice per group. **P<0.01 was considered to be statistically significant in sorafenib-treated group versus Ctrl group, and in Len-circ_0001944-shRNA/sorafenib group versus sorafenib-treated group, as well as in Len-circ_0001944-shRNA/sorafenib/Ferrostatin-1 group versus Len-circ_0001944-shRNA/sorafenib group.