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. 2024 Dec 2;14:29990. doi: 10.1038/s41598-024-81795-z

Table 2.

Treatment outcomes based on different body mass index before and after Solifenacin and estrogen intravaginal cream treatment.

Normal weight
18.5 ≦ BMI<24 (n = 34)
Overweight 24 ≦ BMI<27 (n = 14) Obese
27 ≦ BMI (n = 22 )
p
UDI-6
 Pre-treatment 6.4 ± 3.6 8.9 ± 4.0 7.1 ± 3.7 0.056
 Post-treatment 4.5 ± 3.6 6.1 ± 2.9 5.5 ± 4.3 0.639
 Difference − 2.1 ± 5.2 − 2.1 ± 4.2 − 1.5 ± 3.5 0.954
 P (intergroup) 0.009 0.147 0.107
IIQ-7
 Pre-treatment 6.8 ± 5.6 9.1 ± 5.4 8.0 ± 5.4 0.044
 Post-treatment 5.5 ± 5.7 5.7 ± 3.7 6.1 ± 5.2 0.882
 Difference − 1.3 ± 5.7 − 3.3 ± 6.0 − 2.3 ± 5.0 0.362
 P (intergroup) 0.923 0.358 0.193
OABSS
 Pre-treatment 6.5 ± 3.5 9.5 ± 3.4 8.1 ± 3.4 0.004
 Post-treatment 3.8 ± 2.2 7.7 ± 3.4 7.2 ± 3.1 0.247
 Difference − 2.7 ± 3.8 − 1.7 ± 4.6 − 1.1 ± 3.8 0.392
 P (intergroup) 0.041 0.038 0.252
 Micturition episodes
 Pre-treatment 10.1 ± 3.8 9.0 ± 4.1 8.3 ± 2.5 0.247
 Post-treatment 7.8 ± 3.8 7.9 ± 3.8 7.4 ± 3.4 0.439
 Difference − 2.4 ± 3.4 − 1.2 ± 4.2 − 0.4 ± 3.2 0.501
 P (intergroup) 0.008 0.195 0.646
Nocturia episodes
 Pre-treatment 2.8 ± 1.7 3.2 ± 2.1 2.7 ± 2.1 0.979
 Post-treatment 1.8 ± 1.5 2.5 ± 1.2 2.6 ± 0.9 0.172
 Difference − 0.8 ± 1.3 − 0.7 ± 0.8 0.5 ± 1.5 0.026
 P (intergroup) 0.021 0.096 0.235
Urgency episodes
 Pre-treatment 3.5 ± 3.2 4.6 ± 4.7 3.0 ± 2.6 0.041
 Post-treatment 2.7 ± 2.8 4.0 ± 4.9 2.3 ± 2.1 0.424
 Difference − 0.6 ± 4.9 − 1.8 ± 7.7 − 1.2 ± 3.0 0.407
 P (intergroup) 0.606 0.708 0.166
Urinary incontinence episodes
 Pre-treatment 0.7 ± 1.0 2.7 ± 2.2 1.9 ± 1.5 < 0.001
 Post-treatment 1.2 ± 1.2 2.0 ± 2.2 1.0 ± 1.3 0.234
 Difference 0.6 ± 0.8 − 0.7 ± 3.9 − 0.9 ± 2.0 0.143
 P (intergroup) 0.008 0.632 0.094

Data are presented as mean ± standard deviation or as number (percent) of patients.

UDI-6: the short form of the Urogenital Distress Inventory, IIQ-7: the short form of the Incontinence Impact Questionnaire, OABSS: overactive bladder symptom score.