TABLE 3.
Mathematical analysis of HIV-gpt infectivity dataa generated on the (CCR5)Y14N panel
| Envelope | R | m | EC50b |
|---|---|---|---|
| JRCSF | 0.84 | 6.6 ± 1.6 | 1.3 ± 0.2 |
| S298N | 0.96 | 6.2 ± 0.7 | 1.2 ± 0.08 |
| F313L | 0.95 | 5.2 ± 0.6 | 1.3 ± 0.08 |
| F313I | 0.95 | 7.3 ± 1.0 | 1.1 ± 0.08 |
| N300Y | 0.93 | 5.5 ± 0.8 | 1.3 ± 0.1 |
| SNFL | 0.90 | 3.8 ± 0.9 | 1.5 ± 0.2 |
| SNNY | 0.94 | 5.4 ± 0.7 | 1.1 ± 0.06 |
| NYFL | 0.96 | 6.6 ± 0.7 | 1.2 ± 0.07 |
| SNNYFL | 0.90 | 4.2 ± 0.9 | 0.73 ± 0.07 |
a
The data plotted in Fig. 4 were fitted to equation 9 in reference 32 by using Kaleidagraph (Synergy Software, Reading; Pa.). The calculated linear coefficients are reported in the R column. R values are regression coefficients showing a strong correlation between the magnitudes of the two axes. EC50s and m values are reported as means ± the standard error of the mean as calculated by Kaleidagraph.
b
Expressed as the number of CCR5 molecules per cell (105).