Table 4.
Residual concentrations of DOX in the tissues of BFS following DOX treatment.
| Time | Tissues (μg/kg), mean ± SD, (n = 6) |
|||
|---|---|---|---|---|
| skin + fat | muscle | kidney | liver | |
| 4 h | 1503.5 ± 235.7b | 2826.3 ± 228.8c | 4628.4 ± 282.3a | 3950.9 ± 193.4d |
| 1 day | 692.9 ± 78.3b | 1840.7 ± 344.7c | 3990.0 ± 371.8a | 3136.6 ± 306.2d |
| 3 days | 505.6 ± 92.2b | 1559.1 ± 267.8c | 2172.5 ± 251.7a | 1937.4 ± 219.6a |
| 5 days | 431.1 ± 31.1b | 1089.3 ± 166.5c | 1662.6 ± 137.4a | 1294.6 ± 186.7d |
| 7 days | 366.5 ± 54.3b | 753.9 ± 87.0c | 991.6 ± 134.5a | 713.3 ± 76.9d |
| 10 days | 244.3 ± 45.1b | 437.7 ± 71.4c | 529.1 ± 56.1a | 430.7 ± 43.9d |
| 14 days | 154.7 ± 43.3b | 205.3 ± 31.4a | 211.3 ± 44.7a | 339.2 ± 49.4d |
| 20 days | 121.8 ± 39.7a | 145.4 ± 50.1a | 149.9 ± 21.3a | 234.3 ± 52.2d |
| 26 days | 69.0 ± 24.5b | 30.5 ± 2.0a | 32.6 ± 7.6a | 104.6 ± 14.6d |
| 35 days | – | – | – | 38.0 ± 5.8 |
| 47 days | – | – | – | – |
Different lowercase letters in the same row of the table indicate significant differences (P < 0.05), whereas identical letters denote non-significant differences (P > 0.05).