FIG. 2.
MAP of the genomic region surrounding an HPV18 integration in a cervical carcinoma. The HSR, defined using a mathematical algorithm that weights sequence motifs associated with cellular MARs, demonstrates a significant potential for attachment to the nuclear matrix. Dup is the distance from the IPup to the HSR. In this instance, the position of the downstream viral IP is unknown. The inset shows the full 30-kb analyzed interval, which contains a single HSR. In our study, MAP and HSR boundaries were defined using the MAR prediction algorithm's default detection and clipping parameters. The MAP of the genomic region illustrated here is shown with unclipped peaks for clarity.