TABLE 2.

Mean distances from viral IP to closest HSR (kb)^a

Subset	Virus	dup	ddown
a	HPV	0.57 (n = 7, P < 0.005)	7.3 (n = 10)
	HBV	0.00b(n = 3, P < 0.002)	0.00 (n = 3, P < 0.002)
	SV40	10.2 (n = 2)	0.66 (n = 3, P < 0.01)
	HTLV-1 in ATL		0.09c(n = 3)
b	HPV + HBV in growth control genes	11.6 (n = 7)	5.2 (n = 8)
c	HTLV-1 in HAM/TSP	5.9 (n = 2)	12.8 (n = 8)

^ad_up and d_down give the mean distance from the viral IP to the closest HSR for the following subsets of viral integrations: a, integrations in tumors and transformed cell lines; b, integrations in tumors and cell lines that disrupted genes involved in the control of cellular growth; and c, integrations in nonneoplastic cells. P values are given when observed means are significantly different from values obtained under the assumption of random integration. 

^bWhen an IP occurred within an HSR, D = 0. 

^cUpstream and downstream.