TABLE 2.
Examples of known cytoplasmic sorting signalsa
| Signal | Protein | Sequenceb | Localizationc |
|---|---|---|---|
| Tyrosine based (NPXY) | LDL receptor | TM-12 aa-FDNPVY-32 aa | Internalization |
| Tyrosine based (YXXΦ) | Tfn receptor | 17 aa-LSYTRF-45 aa-TM | Internalization |
| TGN38 | TM-24 aa-SDYQRLNLKL-COOH | TGN | |
| Lamp-1 | TM-RKRSHAGYQTI-COOH | Lysosomes | |
| Lamp-2 | TM-KSIRSGYEVM-COOH | Lysosomes | |
| HLA-DMβ | TM-WRRAGHSSYTPLP-COOH | MIIC | |
| PIgR | TM-79 aa-LAYSAF-141 aa | Basolateral PM | |
| CD-MPR | TM-24 aa-YKYSKV-135 aa | Late endosomes | |
| CI-MPR | TM-42 aa-AAYRGV-19 aa | Late endosomes | |
| Dileucine based | CI-MPR tail | TM-24 aa-LVSFHDDSDEDLLHI-COOH | Late endosomes |
| CD-MPR tail | TM-42 aa-LGEESEERDDHLLPM-COOH | ||
| Ii | NH-MDDQRDLISNNEQLPMLGRR-COOH | MIIC | |
| Acidic clusters | Furin | TM-28 aa-EAWQEECPSDSEEDE-15 aa | TGN |
| Dilysine (KKFF) | ERGIC-53 | -RSQQEAAAKKFF-COOH | Intermediate compartment |
| Adenovirus E3/19K | -KYKSRRSFIDEKKMP-COOH | ER | |
| mGLUR-1 | -FLNIFRRKKPGAGNAKKRQ-16 aa | ER |
a
The HHV-7 U21 C-terminal sequence is TM-SCLDGVQKVLTWPLQHIQKEPVSEKIINLTNLMFGQEPLPKKESLKQQCL-COOH. Modified from tables in Kirchhausen et al. (20) and Marks et al. (23).
b
aa, amino acids; TM, transmembrane region; COOH, C terminus.
c
TGN, trans-Golgi network; PM, plasma membrane; MIIC, MHC class II compartment.