Table 1.
The classical mechanisms of small nucleolar RNAs (snoRNAs) involved in tumorigenesis and progression.
| SnoRNA | Mechanism | Target RNA | Biological function | Related tumor type | Refs. |
|---|---|---|---|---|---|
| SNORD89 | Regulating 2’-O-methylation modification | BIM mRNA | Promoting tumor occurrence and development |
EC | [38] |
| SNORD104 | Regulating 2’-O-methylation modification | PARP1 mRNA | Promoting tumor growth | EC | [39] |
| SNORD60 | Regulating 2’-O-methylation modification | PIK3CA mRNA | Promoting tumorigenesis and progression | EC | [40] |
| SNORD127 | Regulating 2’-O-methylation modification | 18S rRNA | Promoting the activity of cancer stem cells | AML | [41] |
| SNORD17 | Regulating 2’-O-methylation modification | KAT6B mRNA | Promoting vasculogenic mimicry | Glioblastoma | [42] |
| SNORD11B | Regulating 2’-O-methylation modification |
18S rRNA and MIRLET7A1HG(pri-let-7a) mRNA |
Promoting tumor cell proliferation and invasion and inhibiting apoptosis | CRC | [43] |
| SNORA70E | Guiding pseudouridine modification | RAP1B mRNA | Promoting tumor occurrence and development | OV | [45] |
| SNORA73B | Guiding pseudouridine modification | MIB1 mRNA | Promoting tumor cell proliferation, migration, and invasion and inhibiting apoptosis | EC | [46] |
| SNORD42A | Regulating 2’-O-methylation modification | 18S rRNA | Promoting tumor cell proliferation | AML | [50] |
| SNORD45C | Regulating 2’-O-methylation modification | 18S rRNA | / | CC | [51] |
| SNORA24 | Guiding pseudouridine modification | 18S rRNA | Inhibiting tumor development | HCC | [52] |
| SNORD88C | Regulating 2’-O-methylation modification | 28S rRNA | Promoting tumor growth and metastasis and inhibiting autophagy | NSCLC | [53] |
/: no data. SNORDs: C/D box snoRNAs; BIM: B cell lymphoma-2 (BCL-2)-like protein 11; mRNA: messenger RNA; EC: endometrial cancer; PARP1: poly(adenosine diphosphate (ADP)-ribose) polymerase 1; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; rRNA: ribosomal RNA; AML: acute myeloid leukemia; KAT6B: lysine acetyltransferase 6B; CRC: colorectal cancer; RAP1B: RAS-related protein 1B; OV: ovarian cancer; MIB1: mindbomb E3 ubiquitin protein ligase 1; CC: cervical cancer; HCC: hepatocellular carcinoma; NSCLC: non-small cell lung cancer.