TABLE 1.
Summary of distinct and reproducible patterns of transduction in structures of the CNS following intraventricular injection of AAV2-HβH
| Pattern | Structure | Expressiona at mo:
|
||
|---|---|---|---|---|
| 1 | 6 | 12 | ||
| High initial transduction, sustained expression | Amygdala | +++ | +++ | ++ |
| Dorsal and ventral horns, SC | ++ | ++ | ++ | |
| Hypothalamus | +++ | +++ | ++ | |
| Inferior colliculus | ++++ | +++ | +++ | |
| Medulla oblongata | +++ | +++ | +++ | |
| Mitral cell layer, OB | ++++ | ++++ | +++ | |
| Olfactory tubercle | +++ | +++ | ++ | |
| Parasubiculum | +++ | +++ | +++ | |
| Purkinje cell layer, CB | +++ | +++ | ++ | |
| Subiculum | ++ | ++ | ++ | |
| Superior colliculus | +++ | +++ | +++ | |
| Low initial transduction, sustained expression | CA1/CA3 pyramidal layers, HP | + | + | + |
| Caudate putamen | ± | − | − | |
| Geniculate | ± | ± | ± | |
| Inner tier, granule cell layer, DG | ± | ± | − | |
| Interneuron layers, OB | + | ± | ± | |
| Septum | ± | − | − | |
| Substantia nigra | ± | ± | − | |
| High initial transduction, decreased expression | Neocortex | +++ | + | + |
| Outer tier, granule cell layer, DG | ++++ | +++ | + | |
a
Expression based on the number of in situ-hybridization-positive cells in one hemisphere. Symbols: ++++, 201 cells or more; +++, 101 to 200 cells; ++, 31 to 100 cells; +, 10 to 30 cells; ±, 1 to 9 cells; −, no cells. Abbreviations: CB, cerebellum; DG, dentate gyrus; HP, hippocampus; OB, olfactory bulb; SC, spinal cord.