Table 3. NCI In Vitro Testing Results Expressed as GI50, TGI and LC50 Values of Compound SH7s, as Determined in a Five-Doses Screening Assay.
| subpanel/cancer cell lines | compound SH7s |
||
|---|---|---|---|
| GI50 (μM) | TGI (μM) | LC50 (μM) | |
| Leukemia | |||
| CCRF-CEM | 3.0 | 11.3 | >100 |
| HL-60(TB) | 2.3 | 5.7 | >100 |
| K-562 | 3.1 | 16 0.9 | >100 |
| MOLT-4 | 2.0 | 6.0 | >100 |
| RPMI-8226 | 3.1 | 13.5 | >100 |
| SR | 2.0 | 5.8 | >100 |
| Non-small Cell Lung Cancer (NSCLC) | |||
| A549/ATCC | 3.5 | 13.6 | 49.4 |
| EKVX | 3.8 | 16.4 | 61.7 |
| HOP-62 | 4.1 | 16.1 | 43.3 |
| HOP-92 | 2.0 | 7.3 | 37.5 |
| NCI-H226 | 3.2 | 14.6 | 84.0 |
| NCI-H23 | 3.1 | 12.4 | 43.0 |
| NCI-H322M | 3.9 | 14.3 | 41.2 |
| NCI-H460 | 3.5 | 10.4 | 47.3 |
| NCI-H522 | 3.0 | 12.3 | 46.1 |
| Colon Cancer | |||
| COLO 205 | 2.3 | 5.3 | 18.4 |
| HCC-2998 | 3.1 | 8.9 | 32.4 |
| HCT-116 | 2.0 | 4.2 | 8.7 |
| HCT-15 | 3.6 | 14.4 | 42.3 |
| HT29 | 3.6 | 10.9 | 43.9 |
| KM12 | 3.0 | 11.6 | 57.9 |
| SW-620 | 3.9 | 13.8 | 39.8 |
| CNS Cancer | |||
| SF-268 | 3.3 | 14.7 | 49.4 |
| SF-295 | 2.7 | 10.9 | 36.4 |
| SF-539 | 3.1 | 9.9 | 44.2 |
| SNB-19 | 3.9 | 14.7 | 41.0 |
| SNB-75 | 2.3 | 13.3 | 41.8 |
| U251 | 3.3 | 12.3 | 39.3 |
| Melanoma | |||
| LOX IMVI | 2.8 | 8.4 | 33.7 |
| MALME-3M | 2.5 | 7.7 | 34.0 |
| M14 | 3.3 | 12.0 | 39.9 |
| MDA-MB-435 | 2.8 | 9.6 | 55.4 |
| SK-MEL-2 | 2.4 | 5.5 | 20.0 |
| SK-MEL-28 | 3.7 | 13.7 | 55.1 |
| SK-MEL-5 | 1.9 | 3.9 | 7.8 |
| UACC-257 | 3.3 | 12.0 | 38.2 |
| UACC-62 | 2.1 | 4.5 | 9.6 |
| Ovarian Cancer | |||
| IGROV1 | 3.7 | 21.3 | >100 |
| OVCAR-3 | 2.4 | 6.5 | 27.2 |
| OVCAR-4 | 2.9 | 13.1 | 56.0 |
| OVCAR-5 | 3.5 | 14.4 | 70.8 |
| OVCAR-8 | 3.4 | 13.0 | 43.1 |
| NCI/ADR-RES | 24.7 | >100 | >100 |
| SK-OV-3 | 3.7 | 14.0 | 42.9 |
| Renal Cancer | |||
| 786-0 | 1.7 | 3.4 | 6.9 |
| A498 | 2.8 | 8.3 | 29.3 |
| ACHN | 4.0 | 14.2 | 41.0 |
| RXF 393 | 2.6 | 9.8 | 37.8 |
| SN12C | 3.6 | 13.1 | 48.9 |
| TK-10 | 3.9 | 15.3 | 45.3 |
| UO-31 | 3.4 | 15.1 | 41.8 |
| Prostate Cancer | |||
| PC-3 | 2.9 | 11.4 | 77.1 |
| DU-145 | 3.5 | 12.1 | 35.6 |
| Breast Cancer | |||
| MCF7 | 2.7 | 9.2 | 49.1 |
| MDA-MB-231/ATCC | 2.0 | 4.7 | 13.4 |
| HS 578T | 3.4 | 16.9 | >100 |
| BT-549 | 1.8 | 4.4 | 16.1 |
| T-47D | 2.7 | 12.4 | 51.2 |
| MDA-MB-468 | 2.1 | 6.9 | 32.3 |