Table 4. Median In Vitro Growth Inhibitory Concentrations (GI50, μM) of SH7s towards Cancer Cell Line Subpanels.
| subpanel/tumor cell lines |
SH7s |
|
|---|---|---|
| MG-MID (μM)a | selectivity index | |
| leukemia | 2.6 | 1.35 |
| non-small cell lung cancer | 3.6 | 1.05 |
| colon cancer | 3.1 | 1.13 |
| CNS cancer | 3.1 | 1.13 |
| melanoma | 2.8 | 1.27 |
| ovarian cancer | 6.3 | 0.55 |
| renal cancer | 3.1 | 1.12 |
| prostate cancer | 3.2 | 1.11 |
| breast cancer | 2.4 | 1.43 |
| full panel MG-MIDb | 3.5 | |
a
Median value calculated according to the data obtained from NCI’s in vitro disease-oriented human tumor cell screen.
b
GI50 (μM) full panel mean-graph midpoint (MG-MID) = the average sensitivity of all cell lines toward the test agents.