FIG. 1.

Molecular structure and locations of functional domains in LMP-1. LMP-1 contains a short cytoplasmic amino terminus, a transmembrane hydrophobic domain, and a long cytoplasmic carboxy terminus that contains three major signaling domains. CTAR-1 mediates interaction with the TRAFs and is the minor NF-κB-activating region. The location of the TRAF-interacting motif, PXQXT, is indicated. CTAR-2 is the major NF-κB-activating region. Also, CTAR-2 can activate JNK and p38 molecules. Two JAK-3-binding sites are indicated. The JAK-STAT pathway can be activated by the interaction between JAK-3 and LMP-1. The amino acid numbers are shown. The drawing is not to scale.