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. Author manuscript; available in PMC: 2024 Dec 3.
Published in final edited form as: Am Soc Clin Oncol Educ Book. 2018 May 23;38:830–837. doi: 10.1200/EDBK_200773

Figure 1: Scheme of CAR T-cell generation.

Figure 1:

(A) CARs consist of an ectodomain, hinge and transmembrane domain, and endodomain. CARs have been designed with or without costimulatory (costim) signaling domains. As examples 1st and 2nd generation (Gen) CARs are shown. (B) CAR T cells are produced by activating T cells in the presence of cytokines. Once T-cell proliferate, they are transduced with viral vectors encoding CARs. CAR T cells are subsequently expanded with cytokines, and sufficient CAR T cells for preclinical or clinical studies are generated within 9 to 10 days of culture initiating.