Fig. 6.

The distribution of the nano-prodrug in vivo. (a) Biodistribution of free IR780 and IR780@FU-SS-IND NPs in subcutaneous Hepa1-6/FU cells tumor model at various time intervals (0.5, 6, 9, 12, 24 and 48 h) post-injection (The tumor is indicated by a red circle). (b) 48 h after dosing, tissue distribution and tumor accumulation of free IR780 and IR780@FU-SS-IND NPs from sacrificed mice. (c) After 48 h, quantification of uptake of free IR780 and IR780@FU-SS-IND NPs into tumor and organs. n = 3, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant