Table 10.

Univariate and multivariate Logistic regression analysis for the parameters affecting COVID-19 severity and COVID-19 associated mortality (N = 140)

	COVID-19 severity				COVID-19 mortality
	Univariate		#Multivariate		Univariate		#Multivariate
	OR (95% C. I)	P value	OR (95% C. I)	P value	OR (95% C. I)	P value	OR (95% C. I)	P value
Male	0.39 (0.17–0.86)	0.02*	0.73 (0.25–2.17)	0.5	0.5(0.18–1.67)	0.3
Age	1.01 (0.97–1.04)	0.8			1.17 )1.08–1.28)	< 0.001*	1.18 (1.04–1.34)	0.01*
Low vitamin D	2.61 (1.16–6.18)	0.023*	3.61 (1.37–10.4)	0.01*	0.64 (0.41–0.99)	0.045*
High NLR	2.25 (1.01–5.08)	0.041*	1.19 (0.38–3.59)	0.8	1.05 (0.99–1.11)	0.08
High CRP	7.69 (3.06–22.3)	< 0.001*	5.80 (1.60–22.8)	0.009*	1.01 (1.0-1.02)	0.04*
High D-dimer	4.51 (1.98–10.7)	< 0.001*	1.05 (0.27–4.12)	> 0.9	1 (1-1.01)	0.7
High ferritin	2.75 (1.20–6.33)	0.017*	1.59 (0.54–4.71)	0.3	1 (1.00-1.1)	0.6
High LDH	4.55 (1.62–16.3)	0.008*	2.98 (0.83–13.2)	0.12	1 (0.99- 1)	0.3
Genotype (rs4588)
CC (reference)
AA	0.00 (00–00)	>0.9			0.00 (00–00)	0.9
CA	1.08(0.44–2.54)	>0.9			1.08(0.44–2.54)	0.9
Genotype (rs7041)
TT (reference)
GG	1.65(0.50–6.5)	0.4			1.65(0.50–6.52)	0.4
TG	1.60(0.49–6.2)	0.5			1.60(0.49–6.24)	0.5
Severity					4.61 (1.23–19.1)	0.025*	5.78(1.12–29.7)	0.03*
Diabetes					1.78 (0.58–5.42)	0.3
Hypertension					2.2 (0.71–6.62)	0.175
IHD					0	0.9
CKD					8 (1.93–33.1)	0.004*	0.827(0.08–8.4)	0.8
Chronic liver D					1.5 (0.32–7.93)	0.57
Medications
Corticosteroids					0.34(0.07–2.49)	0.21
Remdesivir					0.28(0.06–1.32)	0.12
Actemra					0	> 0.9
Anticoagulant					NA	0.9

OR: Odd’s ratio, C.I: Confidence interval, IHD: Ischemic Heart Disease, CKD: Chronic kidney Disease

#: All variables with p < 0.05 in the univariate analysis were included in the multivariate, *: Statistically significant at p ≤ 0.05, Low-level vitamin D: serum vitamin D level less than 5.1, High NLR: NLR ratio > 10.1, High CRP: CRP serum level > 70, High D dimer: serum D-dimer level > 930, High ferritin: serum ferritin level > 370, High LDH: serum LDH level > 221