Figure 2.

Transcription factor binding site motifs affected by rare single-nucleotide variants in spina bifida cases showing statistically significant enrichment over matched controls. A. Scatterplot displaying the significance of transcription factor motif occurrences in genomic regions of spina bifida cases compared with control regions. B. Top 5 transcription factor motifs with the corresponding fold-change enrichment and logo representation for the most significant motif enrichments in cases vs controls.